Steroid Assays in Paediatric Endocrinology
نویسندگان
چکیده
منابع مشابه
Steroid Assays in Paediatric Endocrinology
Most steroid disorders of the adrenal cortex come to clinical attention in childhood and in order to investigate these problems, there are many challenges to the laboratory which need to be appreciated to a certain extent by clinicians. The analysis of sex steroids in biological fluids from neonates, over adrenarche and puberty present challenges of specificities and concentrations often in sma...
متن کاملRequirement for mass spectrometry sex steroid assays in the Journal of Clinical Endocrinology and Metabolism.
The accurate measurement of hormones is the pivot of modern endocrinology. Although tracing its roots to ancient writings, the modern scientific discipline came into existence after a series of mid-20th century Nobel Prizewinning achievements in identifying and measuring hormones. Arguably the most decisive step was the invention of immunoassay in 1959 (1), originally for peptide hormones but e...
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Paediatric endocrinology is a highly specialised area of clinical medicine with many experts with specific knowledge distributed over a wide geographical area. The European Society for Paediatric Endocrinology (ESPE) is an example of such a body of experts that require regular collaboration and sharing of data and knowledge. This paper describes work, developed as a corollary to the VOTES proje...
متن کاملMolecular Endocrinology and Steroid Hormone Action
potential application of the recent discoveries. For example, decreased expression of adhesion molecules may be a mechanism by which tumor cells escape immune surveillance. New therapeutic modalities are discussed, such as CD4 immunoadhesins for passive AIDS immunotherapy, and a urokinase-antifibrin conjugate that increases the fibrinolytic potency of urokinase. A particularly interesting chapt...
متن کاملSteroid measurement with LC-MS/MS in pediatric endocrinology.
The liquid chromatography-tandem mass spectrometry (LC-MS/MS) is an increasingly common tool in the clinical laboratory. Established applications include routine assays for detecting inborn errors of metabolism and for monitoring therapeutic drugs and steroids. Steroid profiling is a very effective method for distinguishing almost all steroid related disorders. It allows accurate diagnosis and ...
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ژورنال
عنوان ژورنال: Journal of Clinical Research in Pediatric Endocrinology
سال: 2010
ISSN: 1308-5727
DOI: 10.4274/jcrpe.v2i1.1